Inhibition of Lipid Droplet Accumulation in Mouse Macrophages by Stemphone Derivatives
نویسندگان
چکیده
منابع مشابه
The mechanism of action of bufalin in inhibition of lipid droplet accumulation in mouse macrophages.
A cardiotonic glycoside, bufalin, originally isolated from the dried white venom of Chinese toad Bufo gargarizans, was found to inhibit lipid droplet accumulation in mouse macrophages. Bufalin selectively inhibited synthesis of [C]cholesteryl ester (CE), a main component of lipid droplet, from [C]oleic acid and [C]cholesterol with IC values of 8.6 µM and 10 µM, respectively. The postlysosomal m...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2008
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2008.68